Chelsea is fourth in the standings with 51 points from 30 games and City is in second place on 63 points behind runaway leaders Liverpool who have 86.
Liverpool, who thrashed Crystal Palace 4-0 on Wednesday night, will be crowned champions if City fails to win.
Chelsea will welcome back Jorginho from suspension while Man City are without record goalscorer Sergio Aguero.
Time & date:26 June, 01.15 AM
Venue: Stamford Bridge
Chelsea possible starting lineup:
Kepa, Azpilicueta, Christensen, Rudiger, Alonso; Kante, Jorginho, Kovacic; Willian, Giroud, Pulisic
Man City possible starting lineup:
Ederson; Walker, Fernandinho, Laporte, Mendy; De Bruyne, Gundogan, Foden; Mahrez, Jesus, Sterling